肖貴平; 黃占育
福建農(nóng)林大學(xué)科技開發(fā)總公司; 福建農(nóng)林大學(xué)科技開發(fā)總公司 福州350002 ; 福州350002

【中文摘要】 以小鼠為試驗(yàn)動物 ,進(jìn)行靈芝菌絲提取物 (GLME)防治呼吸系統(tǒng)炎癥試驗(yàn)。結(jié)果表明 ,GLME(40mL·kg-1)對由氨水誘發(fā)的咳嗽的抑制率為 5 2 .16 % ,而陽性對照藥 (可待因 10mL·kg-1)的抑制率為 79.33% ;GLME (40mL·kg-1)使具有祛痰作用的酚紅排泌量較對照提高4 19.30 % ,而陽性對照藥 (祛痰止咳沖劑 10mL·kg-1)僅使酚紅排泌量較對照提高 85 .96 % ;GLME(40mL·kg-1)可顯著增強(qiáng)小鼠由二硝基氯苯 (DNCB)所致遲發(fā)型皮膚超敏反應(yīng) ,其OD值比對照提高 4 0 .14 %。由此可見 ,GLME具有止咳、祛痰和增強(qiáng)免疫力的作用 ,且對慢性支氣管炎有較好的防治作用

【英文摘要】 The controlling effect of Ganoderma lucidum mycelium extract (GLME) on the respiratory system inflammation was determined with the mice as testing animal. The results showed that the inhibitory effect of GLME (40mL·kg -1 ) and positive control (codeine 10mL·kg -1 ) on the cough induced by amonia water was 52.16% and 79.33% resp., that the increment rate of GLME (40mL·kg -1 ) and positive control (expectorant and cough mixture 10mL·kg -1 ) for the phenol red excretion amount was 419.30% and 85.96% resp., and that GLME (40mL·kg -1 ) could significantly enhance the delayed hypersensitivity reaction of mouse skin induced by DNCB and the increment rate of its OD value was as high as 40.14%. So, it was concluded in our experiment that GLME had the effects of relieving cough, facilitating expectoration, improving immunity and controlling chronic bronchitis.

【中文關(guān)鍵詞】 靈芝菌絲提取物; 小鼠; 藥理效應(yīng)
【英文關(guān)鍵詞】 Ganoderma lucidum mycelium extract(CLME); Mouse; Pharmacologic effect
【基金】福建省科委資助項(xiàng)目 (98-H - 2 7)部分內(nèi)容

【文獻(xiàn)出處】 食用菌學(xué)報(bào),Acta Edulis Fungi,編輯部郵箱,2002年02期 【DOI】CNKI:SUN:SYJB.0.2002-02-004