【作者】唐慶九; 季哲; 郝瑞霞; 劉艷芳; 楊焱; 張勁松

【Author】TANG Qingjiu; JI Zhe; HAO Ruixia; LIU Yanfang; YANG Yan; ZHANG Jinsong National Engineering Research Center of Edible Fungi; Key Laboratory of Applied Mycological Resources and Utilization; Ministry of Agriculture; People’s Republic of China; Key Laboratory of Agricultural Genetics and Breeding of Shanghai; Research Center of Natural Medicinal Resources; Institute of Edible Fungi; Shanghai Academy of Agricultural Sciences; Shanghai 201106; China

【作者機構(gòu)】國家食用菌工程技術(shù)研究中心; 農(nóng)業(yè)部應用真菌資源與利用重點開放實驗室; 上海市農(nóng)業(yè)遺傳育種重點開放實驗室; 上海市農(nóng)業(yè)科學院天然藥用資源研究開發(fā)中心; 上海市農(nóng)業(yè)科學院食用菌研究所

【摘要】 從靈芝(Ganoderma lucidum)子實體中分離純化得到中性三萜部分,經(jīng)HPLC檢測發(fā)現(xiàn)主要有8個峰,與靈芝三萜酸性部分的峰基本不重疊。靈芝中性三萜部分對多種腫瘤細胞的增殖有抑制作用,并觀察到可誘導腸癌SW620細胞凋亡。

【Abstract】 A neutral triterpene fraction (NTF) isolated from Ganoderma lucidum fruit bodies was shown by HPLC to consist of eight major components which differed from the constituents in an acidic triterpenoid fraction (ATF). The NTF inhibited the proliferation of several tumor cell lines and induced apoptotic bodies in SW620 tumor cells.

【關鍵詞】 靈芝; 靈芝三萜; 抗腫瘤; 細胞凋亡

【Key words】 Ganoderma lucidum; antitumor; neutral triterpene; apoptosis

【基金】上海市科委國際合作項目“靈芝誘導腸癌細胞凋亡的活性成分及作用機制的研究”(編號:044307041)的部分研究內(nèi)容
 

【文獻出處】 食用菌學報,Acta Edulis Fungi,編輯部郵箱,2010年01期

【DOI】CNKI:SUN:SYJB.0.2010-01-014

【分類號】R285